Engineering

Generate variant designs and build new antibodies based on these designs.

Optimized leads have improved developability critical for downstream processing and manufacturing.

• Mutation Designs: Double-click a residue in the Sequence tab, or in the PFA or Liabilities views, to open a mutation design. Mutation designs may be edited. The parental residue may be included in the variant design set or not. A parental residue is usually included if the user suspects the position may be necessary for function, in which case mutating the site would be risky.
• Observations: Click a residue to enter an observation for that IMGT position. These are displayed in the Observations tab and on a clicked residue.
• Generate Variant Designs: Selected sets of designs may be used to generate variant designs. The variant designs may be generated with parental residues as defined in the mutation designs using "Generate Combinations", or all parental residues ignored using "Generate Combinations (Non-Parent)".
• Variant Designs: The generated designs are displayed in the Variant Designs tab. Designs may be deleted or selected for building new antibodies.
• Build New Antibodies: Selected variant designs may be used to build new antibodies. New antibodies are added to the project and the parent antibody assigned.