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Clading (Phylogenetics)

View the sequence-distance relationships between selected entries.

This is helpful in the evaluation of residue variations amongst closely related sequences, diversity amongst the set, and the identification of possible leads with potentially diverse developability characteristics.

  • Tree View: Use the phylogenetic tree to set group alignments. The Clade Distance may be set via the settings value or by dragging the Clade Distance slider.
  • Clustering: Identify families of related sequences. This may be used to evaluate functional differences between the sequences and these difference may be used to aid engineering selections and to generate IP claims around functional positions.
  • Sequence Regions for Clading: Use the Chains and Regions selection boxes to focus the residues used to build the clades.
  • Export
    • Cluster Alignments: Exports the alignments in Excel.
    • Cladogram: Exports the tree as an SVG file.

Clading