Skip to content

Assembler

Rebuild antibodies from their Fvs by selecting from the Domain types: Leader, KC, LC, CH1, Hinge, CH2, CH3-CHS, and Other.

Method

  • Select Entries: The variable regions are selected from the selected entries to populate the Assembler tool. The rows Kappa Chain, Lambda Chain, and Heavy Chain are each populated with a single representative domain.
  • Select Domains: Using the Domains section, expand a domain type, select the desired domain, and drag it to the appropriate row in the proper position relative to the variable and other domains.
  • Build New mAbs: After building the chains, select "Build New mAbs" to create newly assembled antibodies. Each entry's variable domain is combined with the selected constant domains and then paired properly to create new antibodies. The new antibodies are processed and added to the starting Project table.

Assembler

References

  • The Domain sequences were obtained using the IMGT/GENE-DB database.