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Build Models

Generate 3D structural Fv or VHH models for the selected entries.

This option utilizes:

  • ABodyBuilder2 for standard Fv pairs.

  • NanoBodyBuilder2 for single-domain VHH entries.

This process calculates the variable domain structure and automatically updates the entry with its corresponding structural surface properties (e.g., SPH, SPP, SPN, SPCD).

[!NOTE] This builds only the variable domain models, which might not give completely accurate surface properties since residues that would normally be buried by the CL/CH domains in a Fab structure will be exposed to solvent in the Fv model.

[!IMPORTANT] Verify the structure models external to AbLead before relying on their validity! Use the PDB Files interface to download and inspect the models.