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Clinical Comparison

Visualizes the attributes of an entry against the same attribute's ranges in the clinical-stage antibody set from Jain et al.

This tool is useful for comparing the properties of an antibody to the clinical-stage antibody set. Note: While the clinical-stage antibody entries used to define the ranges may have been successfully developed, many might not have been easy to develop. "Better" is better than "in range".

Accessing the Tool

Select at least one antibody in the Project View. Go to the Analysis menu and select Clinical Comparison. This will open the Clinical Comparison workspace in a new tab.

Clinical Comparison

Using the Tool

Human Only

This limits the comparison set to the 127 human sequences rather than the 137 human and mouse sequences.

Column Descriptions

  • Attribute: The comparable attribute from the clinical set.
  • Clinical Range: The range of values for the attribute in the clinical set.
  • Entry Value: The value of the attribute for the entry.

Color Coding

The background color of the entry values indicates how they compare to the distribution of the clinical-stage antibody set:

Categorical Attributes:

  • Green: The entry's category is present in the clinical set.
  • Red: The entry's category is not found in the clinical set.

Numeric Attributes:

  • Green: Values between the 25th and 75th percentiles (inclusive).
  • Yellow: Values between the 5th and 25th percentiles, or between the 75th and 95th percentiles.
  • Orange: Values below the 5th percentile, or above the 95th percentile.
  • Red: Values outside the minimum and maximum ranges observed in the clinical set.

Excel Export

The grid may be exported for inclusion in an ELN or report.

References