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AbLead

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Developability by Design

Antibody sequence and structure analysis to evaluate, rank order, and engineer biotherapeutics.
Identify stable, manufacturable candidates before you invest in the lab.

Ketchem Biotherapeutics Consulting LLC

Welcome to AbLead

AbLead is a comprehensive platform for antibody analysis, liability assessment, and in-silico engineering. It combines sequence-based metrics with structural modeling to evaluate antibody developability and guide in-silico engineering.

System Overview

The platform is designed to streamline the workflow from lead panel rank ordering to analysis to optimization engineering of lead candidates. Key capabilities include:

  • Rank Order Analysis and Lead Selection: Evaluate antibody sequences across a range of developability attributes to rank order and select lead candidates.
  • In-Silico Engineering: Design and evaluate optimization variants directly within the application.
  • Fv Profiling: Identifies closest germline, nearest neighbor, CDR lengths, stability, surface properties, missing or unusual cysteines, potential post-translational modifications, humanness, and isoelectric point. These are used to generate a score for ranking sequences.
  • Visual Analysis: Interactive dashboards for Sequence Alignments, Clading, Liabilities with structure mapping, Positional Frequency and LLM Residue Analysis, Physical Properties, and Engineering combinatorial variant designs.

Getting Started

Account Setup

If you are a new user, you will be prompted to set up your account upon your first login.

  1. Set Password: Choose a strong passphrase.
  2. Timezone: Select your local timezone to ensure accurate timestamps on all your reports.
  3. Legal Disclosure: You must acknowledge the usage terms to proceed.

Dashboard Navigation

Once logged in, the Dashboard is your central hub. From here you can:

  • Import a new project by uploading sequences in FASTA format with paired Fv chains, and optionally uploading associated PDB files.
  • View and label your active Projects.
  • Access your Profile and settings.

Dashboard Overview